1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand

J Med Chem. 1998 May 7;41(10):1557-60. doi: 10.1021/jm970740r.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Guinea Pigs
  • Ligands
  • Piperidines / chemical synthesis
  • Piperidines / chemistry
  • Piperidines / pharmacology*
  • Rats
  • Receptors, Adrenergic, alpha-1 / metabolism
  • Receptors, Dopamine D2 / metabolism
  • Receptors, Muscarinic / metabolism
  • Receptors, Opioid / metabolism
  • Receptors, Serotonin / metabolism
  • Receptors, sigma / metabolism*
  • Sigma-1 Receptor
  • Spiro Compounds / chemical synthesis
  • Spiro Compounds / chemistry
  • Spiro Compounds / pharmacology*
  • Structure-Activity Relationship

Substances

  • Ligands
  • Piperidines
  • Receptors, Adrenergic, alpha-1
  • Receptors, Dopamine D2
  • Receptors, Muscarinic
  • Receptors, Opioid
  • Receptors, Serotonin
  • Receptors, sigma
  • Spiro Compounds
  • spipethiane